Leukocyte activation is not a real problem post-CPB. The leukocyte dynamics associated with CPB result in a high leukocyte population, but these are largely in an inactivated state. If clinicians are concerned about the leukocyte population of the concentrate, they may choose to leukocyte filter the material. Some clinical groups leukocyte filter all blood products as a matter of course. The view of many clinicians is that this should not be necessary.
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